Jayawardene scored 106* while Kaushal Silva made 95 as Sri Lanka reached 318 for 4 at stumps on day two, a lead of 153 runs.
Dubai: Mahela Jayawardene shrugged off three stitches in his hand with a defiant 32nd Test century and led Sri Lanka to a commanding 318 for 4 in the second Test against Pakistan on Thursday.
Jayawardene was unbeaten on 106 off 230 balls with 12 fours in nearly 5-1/2 hours while opening batsman Kaushal Silva (95) narrowly missed out on a maiden century to give Sri Lanka a lead of 153 on day two after Pakistan were bowled out for 165.
Jayawardene needed three stitches between his third and fourth fingers on his left hand after attempting a catch on Wednesday, but was unruffled by the pain as he put on 139 runs with Silva.
Pakistan struck twice inside the first hour and denied Silva a century when offspinner Mohammad Hafeez had him lbw after the Sri Lanka opener faced 220 balls and hit 10 fours and matched the timing of Jayawardene at the crease.
Captain Angelo Mathews frustrated Pakistan more by adding 91 runs with Jayawardene and was unbeaten on 42 at stumps.
Jayawardene was out for 5 and 0 off Bilawal Bhatti in the first drawn Test, but came back strongly when he raised his century off 215 balls with 12 boundaries by cutting the same bowler to third man boundary.
Pakistan could have to pay heavily for letting Mathews off the hook on 6 as wicketkeeper Sarfraz Ahmed dropped a sitter in Rahat Ali's first over with the second new ball. Mathews scored 91 and a match-saving unbeaten 157 in the drawn first Test.
Pakistan's twin success came in the first session when Kumar Sangakkara (26) and Dinesh Chandimal (12) fell to poor shot selection before Silva and Jayawardene guided them to 215-3 by tea.
Several times, Jayawardene pulled his hand off the bat while facing short deliveries, but it didn't deter the confidence of Sri Lanka's most accomplished Test batsman.
Silva also notched his second successive fifty in the series soon after lunch off 133 balls with five fours when he pulled Saeed Ajmal to midwicket boundary.
Jayawardene successfully overturned Bruce Oxenford's leg before wicket decision on 26 when he was ruled out by the umpire. But the TV replays clearly suggested Ali's ball had pitched outside the line of leg stump.
Silva wiped out Pakistan's first-innings score when he cut Ali to point boundary before elegantly driving the left-arm fast bowler through the covers in the same over.
Silva's magnificent 5-1/2 hour knock was ended when he misjudged a sweep and was trapped leg before wicket by Hafeez soon after tea before Mathews and Jayawardene further frustrated Pakistan.
After Sri Lanka resumed at 57 for 1, Ali got his first success of the series by having Sangakkara lbw and Chandimal threw away his wicket by needlessly pulling a delivery from Junaid Khan (2 for 75).
Ali bowled 55 wicketless overs in the drawn first test last week and had to wait for another 14 overs before Sangakkara played him across the line and was out plumb lbw in the sixth over of the day.
Chandimal, who featured in a match-saving century stand with Mathews at Abu Dhabi, started confidently but lost concentration and holed out to Ali at deep fine leg off Khan's short pitched delivery.